February 2022 Grand Rounds

Department of Physical Therapy and Rehabilitation Science Grand Rounds
Tuesday, February 22, 2022, 7:00 AM – 8:00 AM PST


Grand Round Recording




Lou Defrate, PhD

Unraveling the Mysteries of ACL Biomechanics: An In Vivo Imaging Approach

Talk synopsis: This talk will focus on the use of imaging techniques to measure soft tissue deformations in the joint. This work will focus on the interactions between altered biomechanics after ACL injury and the development of early onset OA. Additionally, the mechanisms of ACL injury will also be investigated.

Session moderated by Cathy Hoang and Richard Souza


Dr. DeFrate is a Professor of Orthopaedics, Mechanical Engineering and Materials Science, and Biomedical Engineering at Duke University and Duke University School of Medicine. Dr. DeFrate also serves as the Vice Chair of Biomechanics, Movement, and Imaging Research in the Department of Orthopaedics. He leads the Musculoskeletal Bioengineering Laboratory at Duke, where he focuses on the use of imaging and biomechanics to solve clinically relevant Orthopaedic problems. Dr. DeFrate completed his undergraduate degree in Mechanical Engineering at the University of Pittsburgh, where he got his start doing Orthopaedic research. He then completed a master’s degree and a PhD in Mechanical Engineering at MIT. After graduating, he stayed on the faculty at Harvard Medical School for one year prior to starting his lab at Duke in 2006.

Dr. DeFrate’s work was recognized with a Kappa Delta Young Investigator Award in 2016. To date, Dr. DeFrate has published more than 100 papers in top Orthopaedics and biomechanics journals and has an h-index of 50. Dr. DeFrate also is a standing member of the Skeletal Biology Structure and Regeneration NIH Study Section and serves as an Associate Editor of the Journal of Biomechanics.