October Grand Rounds

Department of Physical Therapy and Rehabilitation Science Grand Rounds
Tuesday, October 19, 2021, 7:00 AM – 8:00 AM PST

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Susanna Rosi, PhD|

Treatment Strategies to Reverse Cognitive and Behavioral Deficits After Brain Injury and Normal Aging

Session moderated by Cathy Hoang and Richard Souza

The Department of Physical Therapy and Rehabilitation Science is starting a bimonthly Grand Rounds that is open to all clinicians and researchers interested in the topic of rehabilitation. For our next session, we have invited Susanna Rosi PhD, to discuss the integrated stress response (ISR)- a conserved mechanism that all cells use to cope with environmental stress. The ISR is activated in the brain after trauma during neurodegenerative diseases and during aging. We previously discovered that interference with the drug-like small-molecule inhibitor (integrated stress response inhibitor, or ISRIB) rescued traumatic brain injury-induced behavioral and cognitive deficits. Studying old male and female mice our studies demonstrated that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain. ISRIB treatment reverses spatial memory deficits and ameliorates working memory in old mice. When we analyzed the brain region responsible for learning and memory and found that ISR inhibition rescues: (i) neuronal function (ii) neuronal structures and (iii) immune response. Thus, pharmacological interference with the ISR emerges as a promising intervention strategy for combating age-related cognitive decline in otherwise healthy individuals.


Susanna Rosi, PhD, is a Professor in the Departments of Physical Therapy and Rehabilitation Science and Neurological Surgery; she is also the Director of Neurocognitive Research in the Brain and Spinal Injury Center (BASIC). Her areas of expertise include, neuroinflammation, brain injury and cognitive functions. She obtained her PhD from the University of Florence, Italy. After completing a short Post-Doctoral Training in Italy; she moved to the University of Arizona for a Post-Doctoral Research Associate position in the Neural System Memory and Aging Center under the guidance of Drs. Carol Barnes and Gary Wenk. She joined the UCSF faculty in 2006 and she received an accelerated promotion to Associate Professor in 2011 and became Director of Neurocognitive Research. She has been able to build national and international recognition in the field of Neuroscience, and among her numerous achievements she recently received the Bridging the Gap Award from the California Institute for Quantitative Bioscience (2015) and was chosen to give the Discovery Talk at the 2015 UCSF Alumni Weekend.


Zoom Information:

Topic: Grand Rounds With Dr. Susanna Rosi

Time: Oct 19, 2021 07:00 AM Pacific Time (US and Canada)

Meeting ID: 924 0168 1286

Password: 721228

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SIP: [email protected]

Meeting ID: 924 0168 1286

Password: 721228